The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment. Taking Depakote during pregnancy for any medical condition puts your baby at risk for serious birth defects that affect the brain and spinal cord and are called spina bifida or neural tube defects.
Other birth defects can affect the structures of the heart, head, arms, legs, and penis and can lower IQ. All women of child-bearing age should talk to their healthcare provider about using other possible treatments instead of Depakote. If the decision is made to use Depakote, you should use effective birth control. Inflammation of your pancreas that can cause death. Increased risk of suicidal thoughts and actions.
Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Call your doctor right away with any changes in your condition.
Do not take Depakote: If you have liver problems, including genetic liver problems e. Alpers-Huttenlocher syndrome ; are allergic to the ingredients or have a genetic disorder called Urea Cycle Disorder UCD For the prevention of migraine headaches if you are pregnant Common side effects include: nausea vomiting dizziness double vision weight gain problems with walking or coordination headache weakness.
When you use this card, you are confirming that you have not submitted and will not submit a claim for this prescription for reimbursement under any federal, state, or government-funded healthcare program, such as Medicare including Part D , Medicare Advantage, Medicaid, Medigap, Veterans Affairs, the Department of Defense, or TRICARE.
In some cases, liver damage may continue despite stopping the drug. Call your healthcare provider right away if you get any of the following symptoms: nausea or vomiting that does not go away, loss of appetite, pain on the right side of your stomach abdomen , dark urine, swelling of your face, or yellowing of your skin or the whites of your eyes.
If you take DEPAKOTE during pregnancy for any medical condition, your baby is at risk for serious birth defects that affect the brain and spinal cord and are called spina bifida or neural tube defects. These defects occur in 1 to 2 out of every babies born to mothers who use this medicine during pregnancy. These defects can begin in the first month, even before you know you are pregnant. Other birth defects that affect the structures of the heart, head, arms, legs, and the opening where the urine comes out urethra on the bottom of the penis can also happen.
Birth defects may occur even in children born to women who are not taking any medicines and do not have other risk factors. Taking folic acid supplements before getting pregnant and during early pregnancy can lower the chance of having a baby with a neural tube defect.
There may be other medicines to treat your condition that have a lower chance of causing birth defects, decreased IQ, or other disorders in your child. All women of childbearing age including girls from the start of puberty should talk to their healthcare provider about using other possible treatments instead of DEPAKOTE.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication.
Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions.
Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness. About Mental Illness Treatments. About Mental Illness Research.
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Your doctor will monitor how much you eat and drink and check you for signs of dehydration, drowsiness, dizziness, and other side effects. For children: Children younger than 2 years old have an increased risk of liver damage while taking this drug, especially if they also take other drugs to treat seizures.
All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:. Your body may process this drug more slowly and you may have more of a sedative effect. Too much of the drug in your body can cause dangerous effects. This medication did not show effectiveness in children for mania. There is no evidence that divalproex is effective for long-term use in mania longer than three weeks. If your doctor would like you to take this drug for a longer period of time, they will check if you still need the drug regularly.
This medication did not show effectiveness in children for migraine prevention. For people with liver disease: If you have liver disease, you may not be able to process this drug as well as you should. You should avoid taking divalproex sodium if you have severe liver problems. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you.
Divalproex sodium oral tablet is used for long-term drug treatment. For manic episodes of bipolar disorder, your doctor will decide whether this is a short-term or long-term drug treatment.
You may also experience more side effects from this drug if you take it on and off. If you take too much: Taking too much of this drug can cause dangerous effects, such as:. If your symptoms are severe, call or your local emergency services or go to the nearest emergency room right away. What to do if you miss a dose: If you forget to take your dose of this drug, take it as soon as you remember. How to tell if the drug is working: For treatment of seizures: You should have fewer seizures.
For treatment of manic episodes of bipolar disorder: You should see a decrease in symptoms caused by the manic phase of bipolar disorder. Your mood should be well-controlled. A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Learn about options such as analgesics and…. How do you know when to start considering a new epilepsy treatment? Learn about the types of treatments available and when to try a new therapy. Medications for bipolar disorder include lithium, anticonvulsants, antipsychotics, antidepressants, and ketamine.
Other birth defects that affect the structures of the heart, head, arms, legs, and the opening where the urine comes out urethra on the bottom of the penis can also happen. Birth defects may occur even in children born to women who are not taking any medicines and do not have other risk factors. Taking folic acid supplements before getting pregnant and during early pregnancy can lower the chance of having a baby with a neural tube defect. There may be other medicines to treat your condition that have a lower chance of causing birth defects, decreased IQ, or other disorders in your child.
All women of childbearing age including girls from the start of puberty should talk to their healthcare provider about using other possible treatments instead of DEPAKOTE. You can enroll in this registry by calling toll-free or by visiting the website, www. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy. Inflammation of your pancreas that can cause death.
Call your healthcare provider right away if you have any of these symptoms: severe stomach pain that you may also feel in your back, nausea or vomiting that does not go away. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; new or worse depression; new or worse anxiety; feeling agitated or restless; panic attacks; trouble sleeping insomnia ; new or worse irritability; acting aggressive, being angry, or violent; acting on dangerous impulses; an extreme increase in activity and talking mania ; other unusual changes in behavior or mood.
How can I watch for early symptoms of suicidal thoughts and actions? Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings.
Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are worried about symptoms. Ask your healthcare provider about the best way to feed your baby.
DEPAKOTE can cause other serious side effects, including: Bleeding problems: red or purple spots on your skin, bruising, pain and swelling into your joints due to bleeding or bleeding from your mouth or nose.
High ammonia levels in your blood: feeling tired, vomiting, changes in mental status. Allergic hypersensitivity reactions: fever, skin rash, hives, sores in your mouth, blistering and peeling of your skin, swelling of your lymph nodes, swelling of your face, eyes, lips, tongue, or throat, trouble swallowing or breathing. Drowsiness or sleepiness in the elderly. This extreme drowsiness may cause you to eat or drink less than you normally would.
Tell your doctor if you are not able to eat or drink as you normally do.
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