If you take glucosamine or chondroitin supplements, tell your health care providers. They can do a better job caring for you if they know what dietary supplements you use. What Are Glucosamine and Chondroitin? More information.
For the Knee or Hip Glucosamine Major studies of glucosamine for osteoarthritis of the knee have had conflicting results. Most participants in the study had mild knee pain. Those who received the prescription drug had better short-term pain relief at 6 months than those who received a placebo. Overall, those who received the supplements had no significant improvement in knee pain or function, although the investigators saw evidence of improvement in a small subgroup of patients with moderate-to-severe pain who took glucosamine and chondroitin together.
In several European studies, participants reported that their knees felt and functioned better after taking glucosamine. The study participants took a large, once-a-day dose of a preparation of glucosamine sulfate sold as a prescription drug in Europe. It may be because of differences in the types of glucosamine used glucosamine hydrochloride in the NIH study vs.
More than 20 studies have looked at the effect of chondroitin on pain from knee or hip osteoarthritis. The quality of the studies varied and so did the results. Joint Structure. For Other Parts of the Body Only a small amount of research has been done on glucosamine and chondroitin for osteoarthritis of joints other than the knee and hip. Chondroitin for osteoarthritis of the hand A 6-month trial of chondroitin in patients with severe osteoarthritis of the hand showed that it may improve pain and function.
Glucosamine for osteoarthritis of the jaw One study of 45 patients with osteoarthritis of the jaw showed that those given glucosamine had less pain than those given ibuprofen. Glucosamine for chronic low-back pain and osteoarthritis of the spine A Norwegian trial involving people with chronic low-back pain and osteoarthritis of the lower spine found that participants who received glucosamine fared the same at 6 months as those who received placebo.
No serious side effects have been reported in large, well-conducted studies of people taking glucosamine, chondroitin, or both for up to 3 years. However, glucosamine or chondroitin may interact with the anticoagulant blood-thinning drug warfarin Coumadin. A study in rats showed that long-term use of moderately large doses of glucosamine might damage the kidneys. Glucosamine might affect the way your body handles sugar, especially if you have diabetes or other blood sugar problems , such as insulin resistance or impaired glucose tolerance.
More to Consider. If your joints hurt, see your health care provider. Some diseases that cause joint pain—such as rheumatoid arthritis—may need immediate treatment. If you take warfarin or have blood sugar problems, make sure you talk to your doctor about potential side effects if you are considering or taking glucosamine or chondroitin supplements.
Help your health care providers give you better coordinated and safe care by telling them about all the health approaches you use. Give them a full picture of what you do to manage your health. Key References.
Archives of Biochemistry and Biophysics. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints—a randomized, controlled, short-term study.
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine. The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature. Osteoarthritis and Cartilage.
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Glucosamine and Chondroitin for Osteoarthritis Pain Research is mixed on whether these supplements help with OA pain and stiffness, but they are safe to try. What Are Glucosamine and Chondroitin?
How Do They Work? Which Form Is Best? Are They Safe? Complementary Therapies View All Articles. Complementary Therapies 12 Supplements for Osteoarthritis Before you buy supplements to treat your OA, see which ones have the best evidence behind them — and which do not.
Complementary Therapies Hypnosis for Pain Relief Learn how this mind-body technique may help relieve arthritis symptoms. Track Your Health Share your experience with arthritis to shape research and patient care for yourself and others. Stay in the Know. Live in the Yes. I Want to Contribute. Therefore, labels may be deceptive 2. Manufacturers willing to have their products tested for purity by a third party tend to have higher standards.
Most research supports the use of glucosamine-sulfate solely for managing osteoarthritis symptoms. The typical glucosamine dosage is 1, mg per day, which you can take at once or in multiple smaller doses throughout the day 2. Glucosamine supplements are made from natural sources — such as shellfish shells or fungi — or manufactured artificially in a lab. Glucosamine supplements are available in two forms 1 :.
Most scientific data indicates the greatest efficacy for glucosamine sulfate or glucosamine sulfate combined with chondroitin. Glucosamine is typically dosed at 1, mg per day. Of the available forms, glucosamine sulfate — with or without chondroitin — is likely the most effective. Possible adverse reactions include 1 :. Glucosamine may worsen blood sugar control for people with diabetes, though this risk is relatively low.
If you have diabetes or are taking diabetes medications, talk to your doctor before taking glucosamine 2. Glucosamine is likely safe for most people.
Some mild gastrointestinal upset has been reported. If you have diabetes, glucosamine may worsen your blood sugar control. Glucosamine exists naturally within your body and plays a vital role in the development and maintenance of healthy joints.
Though glucosamine is used to treat various joint, bone and inflammatory diseases, such as IBD, interstitial cystitis and TMJ, most research only supports its effectiveness for long-term osteoarthritis symptom management. Glucosamine supplements are popular but controversial. This article takes a look at whether or not they are effective at treating arthritis. Complementary and alternative treatments for osteoarthritis may help you manage symptoms.
These can include herbs and supplements like turmeric and…. Treatments for arthritis include over-the-counter and prescription medications, but natural and lifestyle remedies also play a key role.
Find out more…. Cartilage cushions joints and helps them work smoothly. It naturally degenerates with age, which may lead to osteoarthritis. Learn more. Healthy eating can help you recover from knee replacement surgery. Discover some vitamins and minerals that can help, and get some tips on supplements. Health Conditions Discover Plan Connect. Benefits, Dosage and Side Effects. Share on Pinterest. What Is Glucosamine? May Reduce Inflammation. Supports Healthy Joints.
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